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Illustration of STACT ACTM-838 with IL-15plex and eSTING payloads, showing the fusion protein complex and immune activation m

Lead Product: ACTM-838

Close-up image of T-cells engaging a cancer cell, representing the immune system's response in cancer immunotherapy.
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Our lead asset, ACTM-838, delivers a powerful 1,2-punch by combining two immune-activating agents that elicit a potent effect. Our pre-clinical studies have demonstrated reprogramming of the tumor immune state, the eradication of solid tumors, and protection against tumor rechallenging, indicating a strikingly successful anti-tumor memory response by the adaptive immune system. ACTM-838 is advancing through the clinic and is currently in a Phase 1a/b trial.

We believe the STACT™ platform will become an indispensable tool for achieving tipping point efficacy of IO drugs – something that still largely eludes the field of oncology. 

Vertical flowchart of the ACTM-838 mechanism of action, showing tumor antigen release, T-cell priming, and sustained immune r

Our pipeline is built on the STACT™ platform, through which we deploy the biological intelligence of bacteria to treat the untreatable, beginning with cancer.  Our pipeline is built on the STACT™ platform, through which we deploy the biological intelligence of bacteria to treat the untreatable, beginning with cancer.  Our pipeline is built on the STACT™ platform, through which we deploy the biological intelligence of bacteria to treat the untreatable, beginning with cancer.  Our pipeline is built on the STACT™ platform, through which we deploy the biological intelligence of bacteria to treat the untreatable, beginning with cancer.  

Oncology

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Fibrosis

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Undisclosed

ACTM-838

Advanced Solid Tumors

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Indication

Discovery

IND-Enabling

Phase 1

Program

Phase 2

Program

Indication

Discovery

IND-
Enabling

Phase 1

Phase 2

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Advanced Solid Tumors

ACTM-838

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Undisclosed

Oncology

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Undisclosed

Fibrosis

Diagram of the ACTM-838 immune activation process in tumor cells, illustrating each step from eSTING production to memory T-c
Horizontal diagram of ACTM-838 immune pathway, detailing each phase of immune activation from eSTING production to tumor prev
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